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datadragon May 18th, 2018 08:59 PM

DHEA increases Androsterone. Status and Mood.

Androsterone levels (but not allopregnanolone, pregnanolone, and pregnenolone) increased after DHEA supplementation but not after placebo (F 2,42 = 3.3, p < 0.05). Post-DHEA Androsterone levels were higher in women than men [t 63 = 2.9, p < 0.05]. However, in both men and women who met criteria for clinical response on the CES-D (depressive), baseline androsterone levels significantly increased post-DHEA, and the magnitude of the androsterone increase post-DHEA treatment was similar in men and women. In a previous study, the adrenal androgen DHEA, a precursor of the neurosteroid androsterone, produced antidepressant and libido-enhancing effects in patients with midlife depression.

So dhea supplementation increases androsterone (status) levels, mood and libido, more muscle among other things. Women tend to only need 10mg or less as they convert more to testosterone, men it seems can try from 10-25mg, and sometimes 50mg is used temporarily when levels are low to restore them to young person levels, then stick to low levels like 10mg unless they are under regular stress. Larger amounts then 50 is too much.

Some conversion also takes place from Progesterone:

Our body evolved to handle short episodes of stress in order to protect us from say a tiger that is chasing you. The normal reaction upon a stressor is to produce increased quantity of both cortisol and dhea and the release of adrenaline and noradrenaline. When the stress is over, the body reduces the output of cortisol and dhea back to normal levels. When the stress is prolonged, our body prefers to make increasingly larger amounts of cortisol from progesterone and less dhea to remain 'ready' for the stress it expects. One study showed that after just 28 days of continuous stress, cortisol levels had climbed to 240% of starting value while Dhea dropped to 15% of initial levels, which I believe is as the magnesium supply is used up. Unfortunately even after the stress is removed, the body sometimes does not recover and bring these hormones back to normal levels, but instead, remains in the stress response mode with high cortisol and low DHEA output. Finally when the resources like magnesium and potassium are very low as stress proceeds long enough, eventually there is a reduction in cortisol to lower then normal levels with dhea rising back into the normal range ('adrenal fatigue'). Heavy Metals such as Mercury in seafood, anger/rush hour, even caffeine and sugar are also treated by the body as stressors the same as a tiger.

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