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Old May 17th, 2018, 09:04 PM   #1
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Default New Pleasure Pheromone

https://news.uci.edu/2015/10/26/love...-interactions/

When you eat dark chocolate, running, use marijuana, or release the hormone oxytocin through sex, touch or staring into the eyes internally, they all stimulate the production of Anandamide, a motivation, pleasure and happy/bliss neurotransmitter in the brain. Oxytocin is known as the love and bonding molecule. Feelings of love ratchet up your oxytocin levels for example, which in turn dial up your bodys anandamide effects giving us that pleasure.

When scientists stimulated oxytocin release, it increased anandamide creation in the brain. When they blocked anandamide, it also blocked the pleasure and pro social effects of oxytocin which means that oxytocin reinforces social bonding/trust and pleasure by anandamide creation. Interrupting anandamide breakdown further enhanced the pleasure of social contact, and animals treated with a drug that stops anandamide breakdown increasing it behaved as though they enjoyed spending time with their cage mates much more then animals treated with placebo.

Anandamide (AEA) increases in the brain during and following exercise and may be mostly responsible for why exercise makes you happy. A recent animal study similarly found that anandamide might be responsible for producing the "runner's high" in mice.
https://www.ncbi.nlm.nih.gov/pubmed/26438875

In the late 1980s, receptors were found in the brain for THC (tetrahydrocannabinol), the primary psychoactive component in marijuana. But since THC doesnt naturally occur in the body, the presence of these receptors puzzled scientists. The mystery was solved a few years later with the discovery of arachidonylethanolamide, later called anandamide.

Anandamide is a natural neurotransmitter produced in the brain that binds to the CB1 Cb2 THC receptors. Its been called the bliss molecule aptly named after ananda, the Sanskrit word for joy, bliss, or happiness. It is considered an endocannabinoid a substance produced in the body that binds to cannabinoid receptors and now seems to be responsible for much of the natural normal positive feelings in social interactions, bonding, touch, sex, exercise, and love.

Anandamide molecular weight is only 347.53 g/mol, much closer to 'pheromones' most use which are around 270-330. Oxytocin is 3 times that weight. It also should not have negative effects on pregnant women as oxytocin can, and is found naturally in quality dark chocolate for example.

https://medium.com/@mary_c_biles/ana...y-895cdafcf7fe
Those who are 'extra happy' people produce less of the enzyme FAAH (fatty acid amide hydrolase) which is responsible for breaking down a chemical in the body called anandamide

Study: Cannabis Produces the Same Pleasure as Having Sex Regularly
Researchers from the Faculty of Medicine of the National Autonomous University of Mexico, discovered that the use of cannabis (also) activates the same receptor as sexual pleasure, CB1 and releases oxytocin and both activate dopamine, responsible for the sensation of pleasure same as intercourse. They studied how various activities provide us with pleasure, and came to the conclusion that the feelings yielded by marijuana and sex are more similar than previously thought. This pleasure is not obtained only by smoking marijuana, but with other types of consumption, such as ingestion or the application of balms. Cannabis is a potent aphrodisiac, increasing body awareness, greater concentration or an increase in climax. Marijuana just also blocks the breakdown (lessening) after the fact increasing the potency of the effect.
https://www.dinafem.org/en/blog/cann...-pleasure-sex/

Anandamide may also be involved in increasing a protein called Brain Derived Neurotrophic Factor (BDNF). BDNF not only preserves existing brain cells, it also activates brain stem cells to convert into new neurons and effectively makes your brain grow larger, so it has potential for other benefits, as well as for a novel depression therapy.

Last edited by datadragon; May 20th, 2018 at 03:56 AM.
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Old May 18th, 2018, 09:16 PM   #2
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Default Re: New Pleasure and Bliss Pheromone

And where can I buy this molecule?
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Old May 19th, 2018, 07:42 PM   #3
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Default Re: New Pleasure and Bliss Pheromone

Added more info to original post. It is not available yet from a pheromone vendor as I just now released the info publicly (instead of privately for some type of commercial benefit), so that any vendor or anyone in the community is welcome to look into it.


This vendor says its supplied pre-dissolved in anhydrous ethanol, 5mg/ml
https://www.tocris.com/products/anandamide_1339
Distributor network: Fisher Scientific, 300 Industry Drive ,Pittsburgh, PA 15275
tel: 1-800-766-7000

List of vendors:
Anandamide | C22H37NO2 | ChemSpider

https://www.sigmaaldrich.com/catalog...&focus=product

Anandamide (ethanol solution) | Abcam

Oxytocin is sold as a solo 'pheromone' and used in a few blends from several vendors, but vendors selling or those using standalone it usually will have minimal effect due to its molecular weight being difficult to travel through the air. Iso E Super from Cinis Labs on Etsy which has higher concentration in dpg , Sylvamber, or Hedione high cis all help it in this regard as well as other methods of high diffusion or methods to extend its longevity, and does work using those alongside it in my own testing.

That had been why there was so much yes it works/no it doesnt debate as I'm sure some used some popular colognes for example that happened to have contained things like Iso E Super or Hedione (Acqua Di Gio for example). Same issue occurs here and there with vendors who happen to use a heavy molecule like astaxanthin. Androtics 'stealth', once its available standalone for purchase at some point may also turn out to be beneficial in these cases.

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Jdub (May 21st, 2018)
Old May 22nd, 2018, 02:47 AM   #4
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Default Re: New Pleasure and Bliss Pheromone

Okay nice, very interesting. I'm thinking I may consider giving this one a shot.
Interestingly it says to store at -20 degrees C, and let set for 1 hour to room temp before using.... and that it will store 6 months in the cold environment..
Sounds very short lived like TAA .
Also sounds like it does what TAA does too..

I'm just scratching my head on what sort of dosage range would be best to test.. or is this completely shooting in the dark..
Maybe start with a few mcgs, then 10s, and 100s?
I suppose it would help to know how much is naturally flowing through the body on a day to day basis.

Any thoughts, datadragon?
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Old May 22nd, 2018, 05:14 AM   #5
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Default Re: New Pleasure and Bliss Pheromone

This is more of the pleasure effect generated naturally from things like touch, bonding, love, sex and enhanced orgasms, running and other activities and to enhance socializing. Marijuana just also happens to be an enhanced trigger as well for the oxytocin and pleasure part acting on the same CB1/CB2 receptors. Oxytocin is released during orgasm in both sexes, stimulation of the nipples, touch, staring in the eyes. In the brain, oxytocin is involved in social recognition, empathy, and bonding, and might be involved in the formation of trust between people.

This methanandamide version says is a stable anandamide analog ... 361.57 g/mol
https://www.sigmaaldrich.com/catalog...g=en&region=US
https://www.tocris.com/products/r-methanandamide_1121

R(+)-Methanandamide is metabolically stable congener of anandamide. (R)-methanandamide exhibited the highest affinity for the CB1 cannabinoid receptor with a Ki of 20 +/- 1.6 nM, 4-fold lower than that of anandamide (Ki = 78 +/- 2 nM). (R)-methanandamide exhibits high stability to aminopeptidase hydrolysis.

Another candidate: Noladin ether is a stable version of 2-Arachidonylglycerol (2-AG) which triggers CB1 and CB2 (sexual pleasure). NE acts as a full agonist at human CB1 + CB2 receptors
364.56 g/mol

Review. Differences between anandamide and 2-AG | Philosophical Transactions of the Royal Society B: Biological Sciences
https://www.tocris.com/products/noladin-ether_1411

2-Arachidonoylglycerol (2-AG) is an endocannabinoid, an endogenous agonist of the CB1 receptor and the primary endogenous ligand for the CB2 receptor. Anandamide exerts its biological effects through both cannabinoid receptors as partial agonist. The endogenous agonist of the CB1 receptor, 2-arachidonoylglycerol (14, 2-AG), is the arachidonic acid ester of glycerol and has higher affinity and efficacy to CB1 and CB2 receptors than Anandamide. 2-Arachidonoylglyceryl ether (15, 2-AGE or noladin ether) is an ether-linked analog of 2-AG, binds to CB1 and very weakly to CB2 receptor.


Brain effects happen immediately and in minutes at maximum. The actual anandamide seems to be active at least 30 min after a single exposure. It is unknown if it stimulate the release of other endogenous substances or activate biochemical pathways that are sustained beyond this.
The Biodisposition and Metabolism of Anandamide in Mice | Journal of Pharmacology and Experimental Therapeutics

Oxytocin was thought to have just a couple minutes half life at first as well, and below study 20 minutes in brain, but salivary oxytocin seems to remain at least 1 1/2 hours later after an exposure naturally when inhaled. For the moment, oxytocin is available and usable when in combo with diffusion enhancers.
http://journals.plos.org/plosone/art...l.pone.0145104
https://www.ncbi.nlm.nih.gov/pubmed/6831225/

Last edited by datadragon; May 23rd, 2018 at 04:55 AM.
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anandamide , bliss , love , oxytocin , pleasure


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