The World's Largest Pheromone Community

Get Real Pheromones directly from Androtics Pheromone Research at the SmartMones Pheromone Store

Questions about pheromones?
Get Fast, Friendly, No-Obligation Help from Real People at the Pheromone Hotline.
Call 1-800-671-6464 in the USA, or +01 425-786-2001 Internationally

Latest Threads ::.. Androtics.Com store is open Best Post Of The Week 29, July, 2018 Best Post Of The Week 28, July, 2018 Best Post Of The Week 27, July, 2018 Best Post Of The Week 26, June, 2018 hello please reach out: let's compare notes, lessons learned, strategies Hello there Best Post Of The Week 25, June, 2018 Senior new to pheromones and seeking advice

Go Back   PheroTalk > Discussion > Studies & Abstracts

Register Invite Your Friends FAQ Members List Calendar Mark Forums Read
Intranasal oxytocin as strategy for medication-enhanced psychotherapy of PTSD: Salien
Intranasal oxytocin as strategy for medication-enhanced psychotherapy of PTSD: Salien
Published by mrseeker
March 1st, 2017
Default Intranasal oxytocin as strategy for medication-enhanced psychotherapy of PTSD: Salien

About ten percent of people experiencing a traumatic event will subsequently develop post-traumatic stress disorder (PTSD). PTSD is characterized by an exaggerated fear response which fails to extinguish over time and cannot be inhibited in safe contexts. The neurobiological correlates of PTSD involve enhanced salience processing (i.e. amygdala, dorsal anterior cingulate cortex (dACC) and anterior insula (AI) hyperactivity), and reduced top-down inhibitory control over this fear response (i.e. dorsal and ventromedial prefrontal cortex (vmPFC) hypoactivity and diminished structural and functional connectivity between the vmPFC, hippocampus and amygdala). Therefore, dampening the exaggerated fear response (i.e. by reducing amygdala hyperactivity) and enhancing top-down inhibitory control (i.e. by promoting prefrontal control over the amygdala) during psychotherapy is an important target for medication-enhanced psychotherapy (MEP) in PTSD patients. Since the neuropeptide oxytocin (OT) has been found to act on these two processes, we propose that OT is a promising pharmacological agent to boost treatment response in PTSD. Human fMRI studies indicate that intranasal OT attenuates amygdala (hyper)activity and enhances connectivity of the amygdala with the vmPFC and hippocampus, resulting in increased top-down control over the fear response. In addition, intranasal OT was found to attenuate amygdala?brainstem connectivity and to change activity and connectivity in nodes of the salience network (i.e. AI and dACC). Furthermore, OT administration may modulate hypothalamus?pituitary?adrenal (HPA) axis and autonomic nervous system (ANS) function and may enhance social behaviour, which could be beneficial in the therapeutic alliance. We also discuss contextual and interindividual factors (e.g. gender and social context) which may influence the effectiveness of OT in MEP. In all, we propose that intranasal OT given prior to each psychotherapy session may be an effective additive treatment to boost treatment response in PTSD.

Article Tools

Featured Articles
1 Active User(s) Viewing This Topic (0 members and 1 guests):  

intranasal , medicationenhanced , oxytocin , psychotherapy , ptsd , salien , strategy

Similar Threads
Article Article Starter Category Comments Last Post
Medication and the natural phero sig Bolkie MEN's Pheromone Advice, Tricks and Tips 3 January 7th, 2012 02:40 AM
Prescription medication and pheromones srjr27 MEN's Pheromone Advice, Tricks and Tips 2 March 21st, 2009 01:01 PM
Intranasal oxytocin jvkohl Studies & Abstracts 0 December 17th, 2008 04:26 AM
Soldiers and cops: PTSD copycat Lounge 25 September 18th, 2008 06:23 PM
Self Enhanced and other Enhanced Senses? acid_circuit MEN's Pheromone Advice, Tricks and Tips 1 February 7th, 2008 02:07 AM

Article Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off

Forum Jump

All times are GMT +3. The time now is 07:51 AM.

(c) 2002-2015 Androtics Pheromone Research All Rights Reserved Internationally
Article powered by GARS 2.1.9 ©2005-2006
Page generated in 0.10911 seconds with 21 queries