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Old December 17th, 2016, 06:42 AM   #1
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Default Bi605906

BI605906, also called SCHEMBL4470165, is a novel pharmacological inhibitor of TNFα-dependent IκB degradation. In additonally, it also inhits expression of pro-inflammatory mediators IL-6, IL-1b, and CXCL1/2. IKKβ: IC50= 380 nM (when assayed at 0.1 mM ATP) In vitro: BI605906 not only prevents the phosphorylation of physiological substrates, such as p105 and RelA, but also the phosphorylation of the serine residues in IKKβ (Ser177 and Ser181) that trigger its activation.

Last edited by Dee A; December 28th, 2016 at 08:07 AM.
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Old December 26th, 2016, 06:45 AM   #2
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Default Re: Bi605906

Wow, nice. I wonder what the next breakthrough will be.
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Old December 27th, 2016, 06:58 AM   #3
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Default Re: Bi605906

I have no idea what this means...
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Old December 27th, 2016, 08:18 AM   #4
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Default Re: Bi605906

Neither do I, but it sounds exciting (lol) ^^.
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